Autotaxin Production of Lysophosphatidic Acid Mediates Allergic Asthmatic Inflammation
نویسندگان
چکیده
منابع مشابه
Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation.
RATIONALE Bioactive lipid mediators, derived from membrane lipid precursors, are released into the airway and airspace where they bind high-affinity cognate receptors and may mediate asthma pathogenesis. Lysophosphatidic acid (LPA), a bioactive lipid mediator generated by the enzymatic activity of extracellular autotaxin (ATX), binds LPA receptors, resulting in an array of biological actions on...
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ژورنال
عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine
سال: 2013
ISSN: 1073-449X,1535-4970
DOI: 10.1164/rccm.201306-1014oc